THE PROTECTION BY BONE MARROW HOMOGRAFTS OF RABBITS IRRADIATED BY GAMMA RAYS FROM Co$sup 6$$sup 0$
Adult rabbits were irradiated with a lethal dose (1500 r given in 2 750- r doses at a 24-hr interval) from a Co/sup 60/ source. A suspension of 300-700 x 10/sup 6/ homologous bone marrow cells were injected in some irradiated animals 48 hr postirradiation. Control animals died between the 11th and 14th day after irradiation with 1500 r. Peritonitis due to gastrointestinal perforation, pneumonia, and internal hemorrhage were the causes of death, but no purulent infections were observed. The same symptoms were also found in half of the animals irradiated with 1500 r and given bone marrow transplants. These died between the 19th and 24th day. The other half of these animals survived for more than 30 days. In the first 3 weeks a drop in erythtocyte counts occurred and an improvement was noted only in the fourth week in animals surviving after homotransplantation for more than 30 days and in controls that received 1000 r. However, in the animals with transplants the rise, as well as the absolute red cell count, was higher than in the controls given 1000 r. In all animals reticulocytes fell initially to zero, but later rose to a maximum. The maximum appeared first in the animals with transplanted bone marrow, surviving for more than 30 days, next in the animals with the bone marrow surviving for less than 30 days, and finally in the controls that received 1000 r. After a typical abrupt fall of leukocytes in all animals, an early rise was noted in animals with transplanted bone marrow. In the controls that had received 1000 r, a rise occurred but not before the fourth week. In the controls given 1500 r, no sign of recovery was noted. It was concluded that the homotransplants protected the animals from death in the acute stage of radiation disease; later mortality, in view of the symptoms observed, was ascribed to homologous disease. (P.C.R.)
- Research Organization:
- Oncological Research Inst., Bratislava
- NSA Number:
- NSA-17-014065
- OSTI ID:
- 4758027
- Journal Information:
- Neoplasma (Czechoslovakia), Journal Name: Neoplasma (Czechoslovakia) Vol. Vol: 8; ISSN NEOLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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