A FUNCTIONING KIDNEY HOMOTRANSPLANT IN THE DOG
A male beagle dog was given supralethal whole-body irradiation with Co/ sup 60/, 1300 r in a 12-hr period. Eight days after irradiation he received an infusion of homologous bone marrow from an unrelated female beagle. The marrow graft was successful. Female leukocytes appeared in the peripheral blood in normal number. Sixteen days after the marrow graft a kidney was transplanted from the female into the male. Ten days later the male's own kidneys were removed. Except for a brief period of adjustment, blood urea and electrolyte concentrations remained normal. The homotransplanted kidney functioned normally until the death of the animal from intercurrent pneumonic disease 49 days after kidney transplantation and 73 days after irradiation. At autopsy the homotransplanted kidney showed no gross or microscopic abnormality. (auth)
- Research Organization:
- Columbia Univ. Mary Imogene Bassett Hospital, Cooperstown, N.Y.
- NSA Number:
- NSA-15-007228
- OSTI ID:
- 4119129
- Journal Information:
- Surgery (U.S.), Journal Name: Surgery (U.S.) Vol. Vol: 46; ISSN SURGA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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