SPLENIC AND BONE MARROW HOMOGRAFTS IN THE DOG AFTER LETHAL TOTAL-BODY IRRADIATION
Since the injection of bone marrow alone appears to give inadequate protection against the lethal effects of radiation in dogs, an experiment was designed to remedy this by the transplantation of spleen as a source of lymphocytes. Four control dogs given 1000-r Cs/sup 137/ radiation lived 3 to 8 days or an average of 5.5 days. After whole-body irradiation and bone marrow homotransplant the survival time of 5 dogs was from 4 to 13 days with an average of 7.4 days. In 5 dogs receiving 1000 r, bone marrow, and splenic whole-organ homotransplants, the survival times ranged from 3 to 6 days with an average of 4.6 days. There was necrosis of splenic cells, either partial or complete, and leukocyte and platelet counts decreased as in the control group. In 6 dogs receiving 1000 r, bone marrow, and splenic pulp homotransplants, the survival times ranged from 4 to 43 days with an average of 14.2 days. In 5 of the 6 dogs there was a typical decrease in the leukocyte and platelet counts, with death due to the effects of acute irradiation or to infection. In the dog that survived 43 days a return of circulating neutrophils and platelets occurred. It was concluded that the bone marrow and possibly the splenic cell transplant were a success and that the tissues were destroyed later by return of the dog's own immune response mechanism. (P.C.H.)
- Research Organization:
- Univ. of Alberta
- NSA Number:
- NSA-17-015814
- OSTI ID:
- 4748960
- Journal Information:
- Canadian Journal of Surgery (Canada), Journal Name: Canadian Journal of Surgery (Canada) Vol. Vol: 4; ISSN CJSUA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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