THE INFLUENCE OF VITAMIN B$sub 12$ ON THE CONTENT OF NUCLEIC ACIDS IN THE BLOOD-FORMING ORGANS OF IRRADIATED ANIMALS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4757996

Sheremet, Z I; Kazanova, L I

Changes in the content of nucleic acids (biochemical and cytochemical techniques) were investigated in comparison with the peculiarities of myeloid cells in the bone marrow and spleen of guinea pigs during irradiation (300 r), in administration of vitamin B/sub 12/ (10 mu g on alternating days) and in simultaneous action of irradiation and vitamin B/sub 12/. A sharp decline was noted in the cortent of nucleic acids in the bone marrow and a somewhat lesser drop in the spleen of guinea pigs 1, 3, and 7 days after irradiation. Administration of vitamin B/sub 12/ in the first half of radiation sickness caused a greater decrease of DNA in the bone marrow and a more marked aplasma of the bone marrow in the majority of the animals. The content of RNA in the bone marrow and the DNA and RNA level in the spleen showed no essential changes. (auth)

• Research Organization: Inst. of Hematology and Blood Translusion, USSR
• NSA Number: NSA-17-014101
• OSTI ID: 4757996
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 8: No. 1; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
GUINEA PIGS
NUCLEIC ACIDS
QUANTITY RATIO
RADIATION DOSES
RADIATION SICKNESS
RIBONUCLEIC ACID
SPLEEN
VITAMIN B-12
VITAMINS