RECOVERY FROM RADIATION INJURY IN RATS FOLLOWING ADMINISTRATION OF NUCLEIC ACIDS

Technical Report · Sat Oct 31 04:00:00 EST 1959

OSTI ID:4293542

Panjevac, B; Ristic, G; Kanazir, D

The experiments reported were undertaken in order to find out whether the highly polymerized isologous, homologous, and heterologous nucleic acids might have a protective effect on irradiated rats. All the rats, separated in groups, received a single whole-body exposure of 700 and 800 r. The radiation exposure was followed by injection of highly polymerized desoxyribonucleic acid and rat bone-marrow nuclei. The nucleic acids and the bone-marrow were prepared from young rats. The protective action of nucleic acids and bonemarrow suspensions was estimated on the basis of 30days survival, increase of nucleic acid content of the spleen, and increase of body weight, The experimental data showed that the 30-day survival observed after treatment with nucleic acids is dependent upon the dose applied and the amount and nature of the injected protective material. The recovery of irradiated rats treated with nucleic acids was evidenced by the cessation of body weight loss and by an increase of the nucleic acids content of the spleen. Under conditions in which x-irradiated rats received mixtures of DNA + RNA, the results were similar to those observed on rats to which bone-marrow nuclei had been injected. (C.H.)

• Research Organization: Inst. of Nuclear Sciences, "Boris Kidric," Belgrade
• NSA Number: NSA-13-006120
• OSTI ID: 4293542
• Report Number(s): A/CONF.15/P/490
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BODY
BONE MARROW
DNA
NUCLEIC ACIDS
POLYMERS
PREPARATION
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RATS
RECOVERY
RIBONUCLEIC ACID
SPLEEN
SUSPENSIONS
TRANSPLANTS
X RADIATION