THE INFLUENCE OF VERY LOW TEMPERATURES ON THE SENSITIVITY OF THE ASCITES TUMOR TO X IRRADIATION

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Neoplasma (Czechoslovakia)

OSTI ID:4755659

Drasil, V

Ehrlich ascites tumor cells were x irradiated with 1000 to 6000 r at +20, --78, and -192 deg C and their viability tested by intraperitoneal injection in mice. Survival time of the mice was longer after injection of cells irradiated at --78 and --192 deg than those irradiated at 20 deg . The diploid form of the cells was generally more radiosensitive than the tetraploid form. The LD/sub 50/ values at 20, --78, and --192 deg were 4500 r, respectively, for tetraploid cells. The diminished radiosensitivity of ascites tumor cells at low temperatures may be attributed to the lower reactivity of free radicals, formed by radiolysis of water molecules, with cellular constituents. The results differ from those previously found in bone marrow cells, whose radiosensitivity was not temperature dependent. (H.H.D.)

• Research Organization: Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno
• NSA Number: NSA-17-015722
• OSTI ID: 4755659
• Journal Information: Neoplasma (Czechoslovakia), Journal Name: Neoplasma (Czechoslovakia) Vol. Vol: 8; ISSN NEOLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ASCITES TUMOR
BIOLOGY AND MEDICINE
BONE MARROW
CANCER
CHROMOSOMES
CYTOLOGY
FREE RADICALS
LETHAL DOSE
LOW TEMPERATURE
MICE
MOLECULES
PLOIDY
QUANTITY RATIO
RADIATION DOSES
RADIOCHEMISTRY
RADIOSENSITIVITY
SURVIVAL TIME
TRANSPLANTS
TUMORS
VARIATIONS
WATER
X RADIATION