STUDIES ON CELL-SURVIVAL OF IRRADIATED EHRLICH ASCITES TUMOUR. III. A COMPARISON OF THE X-RAY SURVIVAL CURVES OBTAINED WITH A DIPLOID AND A TETRAPLOID STRAIN

Journal Article · Tue May 01 04:00:00 EDT 1962 · Intern. J. Radiation Biol.

OSTI ID:4797901

Silini, G; Hornsey, S

The survival curves obtained with a hypo-diploid Ehrlich ascites carcinoma after irradiation with x rays in either oxygen or nitrogen are compared with those previously reported for a near-tetraploid tumor. The radiosensitivity of the two cell-lines, as defined by the slope of the exponential part of the survival curves, is the same when the irradiations are in oxygen. Anoxia lowers the radiosensitivity of the diploid tumor by a factor of 2.7 and that of the tetraploid tumor by 3.1. The extrapolation of the exponential part of the survival curves to zero dose results in an intercept of 2.4 for the diploid tumor compared with approximately 10 for the tetraploid tumor. The significance of a high extrapolation number in the fractionated radiation treatment of spontaneous tumors is discussed. (auth)

• Research Organization: Hammersmith Hospital, London
• NSA Number: NSA-17-000066
• OSTI ID: 4797901
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 5
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CANCER
CHROMOSOMES
EHRLICH ASCITES
GASES
MATHEMATICS
NITROGEN
OXYGEN
QUANTITY RATIO
RADIATION INJURIES
RADIOSENSITIVITY
TUMORS
X RADIATION