EFFECT OF THE ADMINISTRATION OF ADENINE (LEUCON) ON THE CHANGES OF BLOOD IN IRRADIATION
Adenine, one of the purine bases in nucleic acids and a stimulating agent for-hematopoiesis, was administered to 7 patients wtth cancer of the cervix uteri, who were treated with x rays. The patients were irradiated every day except Sunday with a dose of 400 r and at the same time given adenine (leucon), 50 mg per day. Changes in blood were followed up in respect to content of hemoglobin, number of erythrocytes and leukocytes as well as the percentage of neutrophilic leukocytes and lymphocytes. Number of leukocytes decreased at a minimum when the dose of x rays reached 4000 to 5000 r and thereafter showed tendency to increase, the data seemingly indicate that adenine did not prevent leukocytes to decrease, but affected their recovery after a decrease. Adenine also caused the recovery of the percentage of neutrophils and lymphocytes to the normal level. (Abstr. Japan Med., 2: No. 11, Nov. 1982)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-007835
- OSTI ID:
- 4755003
- Journal Information:
- (Niigata Univ., Japan). Gan no Rinsho, Vol. Vol: 7; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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