HEMORRHAGIC SYNDROME IN RATS FED IRRADIATED BEEF. Progress Report No. 6, July 15, 1961-September 1, 1962

Technical Report · Thu Oct 31 04:00:00 EST 1963

OSTI ID:4754613

Doisy, Jr, E A; Matschiner, J T

Progress is reported in studies on the hemorrhagic syn" drome observed in rats fed irradiated beef. Various fractions of fresh and irradiated beef and other dietary components were assayed for their content of vitamin K. The chick assay method used for the determination of vitamin K is described. Data are included on the vitamin K content of lipid extract from fresh frozen beef. Amino acids were shown to alleviate vitamin K deficiency, the extracted protein from fresh beef was found to be more hemorrhagenic than that of irradiated beef, and the lipid extract from fresh frozen beef was found to have more vitamin K activity than that from irradiated beef. Squalene, vitamin A, and vitamin A acid were shown to produce effects in the chick similar to those in the rat. Results of preliminary studies in rats indicate that the mechanism of anticoagulant action of squalene may be in the bowel. (C.H.)

• Research Organization: Saint Louis Univ. School of Medicine
• NSA Number: NSA-17-016360
• OSTI ID: 4754613
• Report Number(s): NP-12597
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALKENES
AMINO ACIDS
DIET
HEMORRHAGE
INDUSTRIAL APPLICATIONS OF ISOTOPES AND RADIATIONS
IRRADIATION
LIPIDS
MEAT
PROTEINS
QUANTITY RATIO
RATS
SQUALENE
VITAMIN A
VITAMIN K
VITAMINS