HEMORRHAGIC SYNDROME IN RATS FED IRRADIATED BEEF. Final Report, September 1, 1958 to July 15, 1961

Technical Report · Wed Oct 31 04:00:00 EST 1962

OSTI ID:4820728

Doisy, Jr, E A; Matschiner, J T

Results are summarized from a study of mechanisms involved in the induction of the hemorrhagic syndrome in rats fed irradiated beef. lt was found that the addition of vitamin A is necessary to produce low prothrombins. The standard beef diet of Metta and Johnson lowers rat prothrombin if as little as 0.5 i.u. of vitamin A is added per gm of diet, while serious depression occurs if 5 or 50 i.u./gm are added. Other studies showed that casein has a protective effect while cold alcohol extraction makes casein and soy protein more hemorrhagenic. Certain lipids were found to lower prothrombin, notably squalene, while oxidation of soy oil and squalene renders them much more hypoprothrombinogenic. The most hemorrhagenic substance yet studied was found to be vitamin A acid. Its effects were 10 to 50 times more severe than vitamin A acetate in lowering prothrombin. The induced hypoprothrombinemia could be reversed or prevented by the addition of small amounts of vitamin K. (auth)

• Research Organization: Saint Louis Univ. School of Medicine
• NSA Number: NSA-16-006268
• OSTI ID: 4820728
• Report Number(s): NP-11261
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
DIET
HEMORRHAGE
IRRADIATION
LIPIDS
MEAT
PROTEINS
RATS
VITAMIN A
VITAMIN K
VITAMINS