PLASMA CATECHOL AMINE LEVELS AND ADRENAL ASCORBIC ACID CONTENT FOLLOWING / cap beta/-MERCAPTOETHYLAMINE (MEA) ADMINISTRATION

Journal Article · Sun Oct 01 04:00:00 EDT 1961 · Endocrinology (U.S.)

DOI:https://doi.org/10.1210/endo-69-4-746· OSTI ID:4750218

Heiffer, M H; Mundy, R L; Mehlman, B

The effects of MEA on the peripheral plasma catechol amine level and adrenal ascorbic acid content of rats were determined at 10, 30, and 60 min following intraperitoneal injections of 125 mg/kg MEA. An increase of plasma epinephrine concentration occurred 10 minutes after administration of MEA and the elevation persisted throughout the 1-hr observation period. Similar results were obtained after administration of cystamine. Injection of 125 mg/kg MEA to intact rats also caused a significant decrease in adrenal ascorbic acid content at the end of 1 hr as compared with saline control rats. However, MEA had no effect on the concentration of adrenal ascorbic acid of hypophysectomized rats. The results indicate that the decrease of adrenal ascorbic acid of intact rats following MEA treatment is not due to its direct action on the adrenal gland. It is suggested rather that the depletion is due to stimulation of ACTH secretion from the anterior pituitary, which may be brought about by release of epinephrine, probably acting through the hypothalamus. (H.H.D.)

• Research Organization: Walter Reed Army Medical Center, Washington, D.C.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-013932
• OSTI ID: 4750218
• Journal Information: Endocrinology (U.S.), Journal Name: Endocrinology (U.S.) Vol. Vol: 69; ISSN ENDOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACTH
ADRENAL GLANDS
AMINES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD PLASMA
BRAIN
CATECHOL
CYSTAMINE
ETHYL RADICALS
GLANDS
HORMONES
HYPOPHYSECTOMY
ORGANIC SULFUR COMPOUNDS
PHENOLS
QUANTITY RATIO
RATS
SURGERY
VITAMIN C
VITAMINS