ZINC-65 UPTAKE BY THE PROSTATE

Journal Article · Thu Nov 01 04:00:00 EST 1962 · Journal of Urology (U.S.)

OSTI ID:4747475

Verrilli, R A; Brady, L W; Croll, M N; Hunsicker, Jr, W C; Uhlman, R C

Dogs were injected intravenously with 40 to 150 mu C Zn/sup 65/, with and without injections of testosterone, and prostatic radioactivity was followed by external scintiscanning and tissue analyses. The results revealed that dog prostate concentrates Zn/sup 65/ and maintains a significant level 7 to 9 days following intravenous injection of the isotope. The preparation of dogs with testosterone alone or in conjunction with pilocarpine did not significantly alter the concentration of Zn/sup 65/ by the prostate. With external scintiscanning techniques no selective differentiation could be made between the prostate and surrounding tissue. There was no discernible pattern in the distribution of Zn/ sup 65/ throughout prostatic tissue as measured by radioassay of serial tissue slices, by radioautography, or by in vitro scintiscanning of the whole gland or serial slices. Also, there was no difference in the Zn/sup 65/ uptake by prostate gland whether the carrier was ZnCl/sub 2/ or Zn aluconate. (P.C.H.)

• Research Organization: Hahnemann Medical Coll., Philadelphia
• NSA Number: NSA-17-017730
• OSTI ID: 4747475
• Journal Information: Journal of Urology (U.S.), Journal Name: Journal of Urology (U.S.) Vol. Vol: 88; ISSN JOURA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALKALOIDS
BIOLOGY AND MEDICINE
DISTRIBUTION
DOGS
GLANDS
GLUCONIC ACID
HORMONES
METABOLISM
PILOCARPINE
PROSTATE
RADIOAUTOGRAPHY
SCINTILLATION COUNTERS
TESTOSTERONE
TISSUES
ZINC 65
ZINC CHLORIDES
ZINC COMPOUNDS