Uptake of radiolabeled testosterone, 5-$alpha$-dihydrotestosterone, estradiol, and pregnenolone by canine prostate

Journal Article · Fri Feb 01 04:00:00 EDT 1974 · J. Nucl. Med., v. 15, no. 2, pp. 94-97

OSTI ID:4351154

Sturman, M F; Beierwaltes, W H; Prakash, S; Ryo, U Y; Ice, R D; Gitomer, W

Twenty-five male dogs received injections into the common sacral artery of tritium-labeled testosterone, 5- alpha -dihydrotestosterone, estradiol, or pregnenolone. No advantage is prostatic percent uptake was achieved by injecting radiolabeled 5- alpha dihydrotestosterone as compared with its prohormone, testosterone. An increase in the specific activity of 5- alpha - dihydrotestosterone by an order of magnitude was accompanied by a similar increase in percent uptake. Attempts to increase the binding capacity or binding affinity by pretreatment with testosterone had no effect. Attempts to desaturate the binding sites of endogenous androgens by pretreatment with castration was without effect. Although the same percent uptake was achieved with labeled estradiol, the uptake of the common precursor pregnenolone with the same specific activity resulted in an order of magnitude less uptake in percent dose/gm of prostate. These uptakes were not achieved using the intravenous route of administration. (auth)

• Research Organization: Univ. of Michigan, Ann Arbor
• NSA Number: NSA-29-021292
• OSTI ID: 4351154
• Journal Information: J. Nucl. Med., v. 15, no. 2, pp. 94-97, Journal Name: J. Nucl. Med., v. 15, no. 2, pp. 94-97; ISSN JNMEA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*PROSTATE-- RADIONUCLIDE KINETICS
*TRITIUM-- UPTAKE
DIAGNOSTIC TECHNIQUES
DOGS
ESTRADIOL
HYDROXYPREGNENONE
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOISOTOPE SCANNING
RADIONUCLIDE ADMINISTRATION
TESTOSTERONE
TISSUE DISTRIBUTION
TRACER TECHNIQUES TISSUE DISTRIBUTION