Testosterone biotransformation by the isolated perfused canine pancreas

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Pancreas; (USA)

DOI:https://doi.org/10.1097/00006676-199101000-00014· OSTI ID:5894433

Fernandez-del Castillo, C; Diaz-Sanchez, V; Varela-Fascinetto, G; Altamirano, A; Odor-Morales, A; Lopez-Medrano, R M; Robles-Diaz, G ^[1]

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1. Instituto Nacional de la Nutricion Salvador Zubiran, Mexico City (Mexico)

There is strong evidence indicating that the pancreas is under the influence of sex steroid hormones, and that it may even participate in their biosynthesis and metabolism. In the present study, (3H)testosterone was perfused into the isolated canine pancreas, and measured in the effluent with several of its metabolites (5 alpha-dihydrotestosterone, androstenedione, and estradiol). Results show that testosterone is readily transformed by the canine pancreas. The main product found in the effluent is androstenedione. The testis and spleen were also perfused with (3H)testosterone and used as controls. In both cases, this hormone appeared mostly unchanged in the effluent as compared to the pancreatic perfusion (p less than 0.0001). From our data, we conclude that the canine pancreas has the capacity to transform sex steroid hormones, and could be considered an extragonadal site of sex steroid biosynthesis.

• OSTI ID: 5894433
• Journal Information: Pancreas; (USA), Journal Name: Pancreas; (USA) Vol. 6:1; ISSN PANCE; ISSN 0885-3177
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL FUNCTIONS
BODY
DIGESTIVE SYSTEM
DOGS
ENDOCRINE GLANDS
FUNCTIONS
GLANDS
GONADS
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
MALE GENITALS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PERFUSED ORGANS
SPLEEN
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES