Cyclotron-produced /sup 62/Zn: its possible use in prostate and pancreas scanning as a /sup 62/Zn amino acid chelate. [Rats, dogs, monkeys, /sup 65/Zn]
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:7094378
Zinc-62 is a positron emitter that localizes in pancreas, prostate, and liver. Cyclotron-produced Zn-62 was separated by column chromatography and evaluated in vivo as the chelate of five amino acids and also as /sup 62/ZnCl/sub 2/. Tissue-distribution studies were done in normal animals from 0.7 to 23 hr after intravenous administration. Pancreas-to-liver ratios (per gram) of about 1.0 were found at 1.5 hr in studies on rats, dogs, and monkeys. Pancreas was as difficult to separate from liver in Zn-62 (amino acid) images as in (/sup 75/Se) selenomethionine images. Some studies were done with Zn-65 to determine the effects of carrier zinc and molar ratios of ligand. The highest ratio of pancreas to liver in these studies was 1.44. This uptake ratio decreases with increasing amounts of histidine, but ratio is increased by adding carrier zinc because there results a decrease in liver uptake and no change in the pancreas uptake. There is sufficient specificity of pancreas and prostate uptake to make feasible emission computed tomography with Zn-62.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 7094378
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:8; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
CYCLIC ACCELERATORS
CYCLOTRONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTIDINE
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIVER
MALE GENITALS
MAMMALS
MONKEYS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PRIMATES
PROSTATE
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
VERTEBRATES
ZINC 62
ZINC 65
ZINC ISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
CYCLIC ACCELERATORS
CYCLOTRONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTIDINE
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIVER
MALE GENITALS
MAMMALS
MONKEYS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PANCREAS
PRIMATES
PROSTATE
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
VERTEBRATES
ZINC 62
ZINC 65
ZINC ISOTOPES