Development of positron emitting radionuclides for imaging with improved positron detectors. [/sup 82/Rb, /sup 62/Zn, /sup 64/Cu, /sup 67/Ga]

Conference · Fri Oct 01 04:00:00 EDT 1976

OSTI ID:7124666

Yano, Y

Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced /sup 82/Rb; cyclotron-produced /sup 62/Zn; and reactor-produced /sup 64/Cu. Investigation of the /sup 82/Sr (25 d)--/sup 82/Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of /sup 82/Rb and the breakthrough of /sup 82/Sr were determined for newly prepared columns and for long term elution conditions. Spallation-produced /sup 82/Sr was used to charge a compact /sup 82/Rb generator to obtain multi-millicurie amounts of /sup 82/Rb for myocardial imaging. Zinc accumulates in the islet cells of the pancreas and in the prostate. Zinc-62 was produced by protons on Cu foil and separated by column chromatography. Zinc-62 was administered as the amino acid chelates and as the ZnCl/sub 2/ to tumor and normal animals. Tissue distribution was determined for various times after intravenous injection. Pancreas-liver images of /sup 62/Zn-histidine uptake were obtained in animals with the gamma camera and the liver uptake of /sup 99m/Tc sulfur colloid was computer subtracted to image the pancreas alone. The positron camera imaged uptake of /sup 62/Zn-histidine in the prostate of a dog at 20 h. /sup 64/Cu was chelated to asparagine, a requirement of leukemic cells, and administered to lymphoma mice. Uptake in tumor and various tissues was determined and compared with the uptake of /sup 67/Ga citrate under the same conditions. /sup 64/Cu-asparagine had better tumor-to-soft tissue ratios than /sup 67/Ga-citrate.

• Research Organization: California Univ., Berkeley (USA). Lawrence Berkeley Lab.
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 7124666
• Report Number(s): LBL-4785; CONF-761060-7; IAEA-SM-210/123
• Country of Publication: United States
• Language: English

Related Subjects

440100 -- Radiation Instrumentation
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CAMERAS
CARDIOVASCULAR SYSTEM
COLLOIDS
COPPER 64
COPPER ISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE GLANDS
EVEN-EVEN NUCLEI
GALLIUM
GAMMA CAMERAS
GLANDS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPHOMAS
MALE GENITALS
MAMMALS
METALS
MICE
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NEOPLASMS
NUCLEAR REACTIONS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PANCREAS
POSITRON CAMERAS
PROSTATE
RADIOCOLLOIDS
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
RUBIDIUM 82
RUBIDIUM ISOTOPES
SCINTISCANNING
SPALLATION
STRONTIUM 82
STRONTIUM ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
ZINC 62
ZINC ISOTOPES