Pancreas accumulation of radioiodinated HIPDM in mice and rats

Journal Article · Mon Jul 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5410784

Yamamoto, K; Som, P; Srivastava, S C; Meinken, G E; Brill, A B

High pancreatic affinity for /sup 131/I-labeled HIPDM was observed in mice and rats. Although the brain uptake of (/sup 131/I)HIPDM is very fast, the pancreatic uptake is rather slow. The pancreas to liver ratios are higher than those obtained with routinely used pancreatic agent (/sup 75/Se)selenomethionine. An increase in liver uptake and decrease in pancreatic uptake was observed at higher dose of carrier HIPDM, which resulted in lower pancrease to liver ratios. HIPDM is a new type of compound which shows predilection for pancreas. Our results suggest that (/sup 123/I)HIPDM might be a useful agent for pancreas imaging.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5410784
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MICE
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SPLEEN
TISSUE DISTRIBUTION
VERTEBRATES