Accumulation of radioiodinated L-. cap alpha. -methyltyrosine in pancreas of mice: concise communication. [/sup 131/I, /sup 123/I]

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5606776

Tisljar, U; Kloster, G; Ritzl, F; Stoecklin, G

L-3-iodo-..cap alpha..-methyltyrosine, labeled with either I-131 or I-123, has a high pancreatic specificity in mice. A pancreas-to-liver ratio of 8.6 +- 2.7 is observed during the first hour after i.v. injection. Accumulation is also prominent in the kidneys, but excretion of the radioagent is rapid, 50% of the activity being eliminated during 90 min. Compared with L-(/sup 75/Se)selenomethionine, the compound currently used for pancreatic imaging, L-3-(/sup 123/I) or (/sup 131/I)iodo-..cap alpha..-methyltyrosine has a greater pancreas-to-liver ratio, a shorter physical half-life and biological half-time, and better decay characteristics.

• Research Organization: Kernforschungsanlage Julich, Germany
• OSTI ID: 5606776
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
BODY
CARBOXYLIC ACIDS
CLEARANCE
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
IODINE 123
IODINE 131
IODINE ISOTOPES
ISOLATED VALUES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
METHIONINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PANCREAS
RADIATION DOSE DISTRIBUTIONS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SELENIUM 75
SELENIUM ISOTOPES
SPECIFICITY
TYROSINE