Growth-hormone and somatostatin effects on (/sup 75/Se)selenomethionine uptake by the pancreas

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5734033

Atkins, H L; Som, P

The imaging of the pancreas with (/sup 75/Se)selenomethionine has a low rate of reliability. This study was carried out in order to elucidate some factors that may be important in affecting the degree of uptake of the tracer by the pancreas. Studies were carried out in animals to observe the effects of growth-hormone (GH), somatostatin (SRIF), L-DOPA, and apomorphine administration on the distribution of (/sup 75/Se)selenomethionine. Intravenously administered GH significantly depressed pancreatic uptake of Se-75 in mice and dogs and depressed the pancreas-to-liver concentration ratio (P/L). The effect of i.p. GH in mice was to decrease the P/L ratio, but the decrease in pancreatic uptake was not statistically significant. There was also a greater effect of GH in dogs than in mice, with pancreatic uptake decreasing from 5.60 +- 2.17% to 1.24 +- 0.96% and the P/L from 4.78 +- 1.85 to 0.97 +- 0.73. L-DOPA and apomorphine produced effects similar to GH in mice. SRIF in small doses had little effect, but in larger doses it enhanced pancreatic uptake, although not affecting P/L. The results indicate that hypothalamic factors may be important in affecting the function of the exocrine pancreas. Both L-DOPA and apomorphine are known to stimulate GH production through hypothalamic-pituitary pathways. In addition to suppressing GH release, SRIF may have direct effects on the exocrine pancreas.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 5734033
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALOIDS
AMINO ACIDS
ANALGESICS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DOGS
DOPA
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
HORMONES
HYDROXY ACIDS
IMAGES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICE
MORPHINE
NARCOTICS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
RODENTS
SCINTISCANNING
SELENIUM 75
SELENIUM ISOTOPES
STH
UPTAKE
VERTEBRATES