SE$sup 75$-SELENOMETHIONINE FOR VISUALIZATION OF THE PANCREAS BY ISOTOPE SCANNING
Journal Article
·
· Radiology (U.S.)
OSTI ID:4829347
The pancreas uptake of amino acids is a reflection of the rapid rate of synthesis of the digestive enzymes. From 5 to 10 per cent of most amino acids are found in the pancreas within an hour after administration. The chemical similarity of selenium and sulfur is so close that the substitution of Se/sup 75/ for sulfur within a methionine molecule results in an analog which has all the properties of amino acids including incorporation into proteins. The physical properties of Se/sup 75/ (half-life, 128 days; principal gamma ray, 0.27 Mev) are well suited to scanning. Using Se/sup 75/-selenomethionine prepared by yeast biosynthesis, more than 50 patients have been scanned. Since the pancreatic tissue itself is not labeled, a protocol must be used which favors enzyme synthesis within the pancreas but avoids any stimulus which would cause pancreatic secretion. In addition, it appears that prolonged food deprivation (overnight or longer) favors uptake in the liver. The following procedure has been temporarily adopted: Three to four hours following a high protein breakfast, the pancreas is stimulated to empty by a dose of mixed secretin and pancreozymin; one hour later, 3 to 3.5 microcuries/kilogram of Se/sup 75/-selenomethionine are given intravenously, and scanning is started one half hour after injection. It has been possible to visualize the pancreas in about two-thirds of the patients scanned. To date, no scans have been done on patients with known pancreatic disease. The estimated dose to the patient from this procedure is about 0.6 rad, total body, delivered over several months. (auth)
- Research Organization:
- Rosweil Park Memorial Inst., Buffalo
- NSA Number:
- NSA-16-020114
- OSTI ID:
- 4829347
- Journal Information:
- Radiology (U.S.), Journal Name: Radiology (U.S.) Vol. Vol: 78; ISSN RADLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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