MODEL EXPERIMENT ON CHEMICAL RADIATION PROTECTION. PART III. PROTECTIVE EFFECTS OF NON-REDUCING MATERIALS AGAINST PERMEABILITY DISTURBANCES BY X-RAY IRRADIATED ERYTHROCYTES (in German)
A large number of non-reducing agents (amino acids, carbonic acids, amines, urea, and phenyl urea) were tested with roentgen hemolysis and preceding disturbances of permeability of the erythrocyte membrane (cell distension, loss of potassium) for a protective effect against x rays and were compared with the reducing cystein. The functional groups (COOH, NH/sub 2/, OH, and SH) causatively participate in the protective action of the aliphatic compounds. The non-reducing groups (COOH, NH/sub 2/, and OH) are capable to attract oxidizing radicals from oxidizable objects in basically the same way, as the reducing SH- group; thereby they loose their protective action. Since oxidizability of the non-reducing groups is slight compared to the oxidizability of the reducing SH- group, their protective action against radiation is weak accordingly. The strong protective action of aromatic compounds depends on the benzoid-ringlike structure. Presumably the delocalized pi -electrons of this structure bring about such a neutralization of the irradiating energy that the aromatic substance can be operative repeatedly in the same way. In this connection the concept on the mechanism of extinction of fluorescence'' in uv-radiated solutions, and on energy-transfer by resonance'' is pointed out. Besides the possibility is discussed, that even in the presence of water direct effects of radiation could participate more strongly than was generally accepted in the last decade. (auth)
- Research Organization:
- Universitat, Freiburg i. B.; and Heiligenbert-Instituts, Ger.
- NSA Number:
- NSA-17-017942
- OSTI ID:
- 4744972
- Journal Information:
- Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 120; ISSN STRAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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Related Subjects
AMINO ACIDS
BENZENE
BIOLOGY AND MEDICINE
CHEMICAL REACTIONS
CYSTEINE
DIFFUSION
ELECTRONS
ENERGY
ERYTHROCYTES
FLUORESCENCE
HEMOLYSIS
IMMUNITY
IRRADIATION
ORGANIC ACIDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
PHENYL RADICALS
POTASSIUM
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RESONANCE
SOLUTIONS
TESTING
ULTRAVIOLET RADIATION
UREA
WATER
X RADIATION