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Interaction of free fatty acids with the erythrocyte membrane as affected by hyperthermia and ionizing radiation

Journal Article · · Bioscience Reports; (USA)
DOI:https://doi.org/10.1007/BF01116574· OSTI ID:6645095
;  [1]
  1. K. Marcinkowski Academy of Medicine, Poznan (Poland)
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The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (10:0), lauric (12:0), myristic (14:0), oleic (cis-18:1) and elaidic (trans-18:1) acids on the osmotic resistance of human erythrocytes was investigated. The results are summarized as follows: (A) not only at 37 degrees, but also at 42 and 47{degrees}C lauric acid (12:0) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection against hypotonic hemolysis occurs, without altering the minimum concentration for 100% hemolysis.

OSTI ID:
6645095
Journal Information:
Bioscience Reports; (USA), Journal Name: Bioscience Reports; (USA) Vol. 10:2; ISSN 0144-8463; ISSN BRPTD
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BODY TEMPERATURE
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
FUNCTIONS
GAMMA RADIATION
HEMOLYSIS
HYPERTHERMIA
IONIZING RADIATIONS
LYSIS
MAMMALS
MAN
MATERIALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIATIONS
VERTEBRATES