THE ROLE OF THE PROTECTIVE ACTION OF RADIOPROTECTORS (CYSTEINE AMINE, CYSTINE AMINE, AND AET) ON THE RADIOMIMETIC EFFECT CAUSED BY OLEIC ACID OXIDATION PRODUCTS

Journal Article · Mon Apr 01 04:00:00 EST 1963 · Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals

OSTI ID:4716990

Kakushkina, M L; Korolev, M P; Kudryashov, Yu B

Oxidized oleic acid (OOO) shows a similar cytotoxilogical effect as that caused by radiation damage. Thus, it appears that the oxidation products of unsaturated fatty acids take part in the primary reactions occurring in the biosubstrate during irradiation. A 2% solution of human erythrocytes in 0.9% NaCl was less stable to the hemolytic effect of 0.002N HCl when incubated with 6 x 10/sup -3/ mg/ml of a standard OOO (oxidized oleic acid) preparation for 15 minutes at 37 un. Concent 85% C. A similar decrease in resistance to hemolysis by HCl was observed when the solution of erythrocytes was given a Co/sup 60/ dose of 100 to 1000 kr. The addition of a radioprotective agent such as cysteine amine resulted in an almost complete restoration to normal of the irradiated erythrocytes. AET was the most effective protective agent against the effects of radiation, and against the radiomimetic effects of OOO (oxidized oleic acid). The compound alpha -alanine had no protective effect. Cysteine amine was more effective against radiation than against the radiomimetic effect of OOO. The results indicated that there is a similarity between the radiation damage and radiomimetic damage to living cells. The stability of erythrocytes to hemolysis can be used as a simple biological model for a rapid preliminary evaluation of radioprotective agents. (TTT)

• Research Organization: Moscow State Univ.
• NSA Number: NSA-17-023218
• OSTI ID: 4716990
• Journal Information: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals, Journal Name: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals Vol. Vol: 149; ISSN DANKA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AET
ALANINE
ALANINE-ALPHA
AMINES
AMINO ACIDS
BIOLOGY AND MEDICINE
COBALT 60
CYSTEINE
CYSTINE
EFFICIENCY
ERYTHROCYTES
HEMOLYSIS
HYDROCHLORIC ACID
ISOMERS
MAN
ORGANIC ACIDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIATION PROTECTION
RECOVERY
SODIUM CHLORIDES
SOLUTIONS
TEMPERATURE
TOXICITY
VELOCITY