THE EFFECT ON ESCHERICHIA COLI B OF RADIOPROTECTORS PRODUCED BY FERMENTATION

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Archiv fuer Mikrobiologie (West Germany) Superseded by Arch. Microbiol.

OSTI ID:4737880

Hernadi, F; Bekesi, I; Nagy, Z; Jeney, A; Valyi-Nagy, T

The possibility of the formation of a radioprotectant compound during bacterial growth was investigated. The radioprotective activity of several hundred fermentation liquids was examined. Of the fermentation liquids tested, good protective ability was rendered, mainly after acid hydrolysis, by the fermentation liquor from a Penicillium notatum strain used in industry. This agent was shown to be D-penicillamine. Its radioprotective activity and its ability to reduce the toxicity of nitrogen mustard were compared with the effect of other well-known radioprotectants, on an equimolar basis. Its protective ability on E. coli B against LD/sub 50/ doses of x rays and nitrogen mustard was about the same as that of cysteine. However, it was only half as effective against x radiation as cysteamine and AET. It was less effective in protecting the cells against radiation than in assisting their recovery from radiation injury. (H.H.D.)

• Research Organization: Debrecen Medical Univ., Hungary
• NSA Number: NSA-17-017802
• OSTI ID: 4737880
• Journal Information: Archiv fuer Mikrobiologie (West Germany) Superseded by Arch. Microbiol., Journal Name: Archiv fuer Mikrobiologie (West Germany) Superseded by Arch. Microbiol. Vol. Vol: 44; ISSN ARMKA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACIDITY
AET
AMINES
BACTERIA
BIOLOGY AND MEDICINE
CHEMICALS
CYSTEINE
ESCHERICHIA COLI
FERMENTATION
HYDROLYSIS
MEA
NITROGEN MUSTARD
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PENICILLAMINE
PENICILLIUM
RADIATION DOSES
RADIATION INJURIES
RADIATION PROTECTION
RECOVERY
TOXICITY
X RADIATION
YEASTS