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Protection by dinitrophenol against radiation-induced hemolysis in hen erythrocytes. [In vitro. gamma. irradiation]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574939· OSTI ID:6538875
;

Hen erythrocytes were ..gamma..-irradiated (up to 15 kR) and incubated at 37/sup 0/C for 20 hr in a slightly hypotonic saline solution (0.10 M NaCl buffered with 5 mM phosphate, pH 7.4) to which 2,4-dinitrophenol, glucose, NaF, or pyruvate were added in different combinations. Hemolysis was measured at the end of the incubation period. Dinitrophenol (2 x 10/sup -4/ M) reduced the radiation-induced hemolysis in both ATP-containing and ATP-depleted erythrocytes. Glucose (10 mM) and pyruvate (10 mM) antagonized the protective effect of dinitrophenol against radiation-hemolysis. NaF suppressed the antagonistic action of glucose on the protective effect of dinitrophenol.

Research Organization:
Univ. Hospital, Oran, Algeria
OSTI ID:
6538875
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 76:1; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ALKALI METAL COMPOUNDS
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIRDS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CHICKENS
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DINITROPHENOL
DISEASES
DISPERSIONS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
FLUORIDES
FLUORINE COMPOUNDS
FOWL
GAMMA RADIATION
GLUCOSE
HALIDES
HALOGEN COMPOUNDS
HEMOLYSIS
HEXOSES
HYDROXY COMPOUNDS
IN VITRO
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETO ACIDS
LYSIS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NITRO COMPOUNDS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHENOLS
PYRUVIC ACID
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
SACCHARIDES
SODIUM COMPOUNDS
SODIUM FLUORIDES
SUSPENSIONS
VERTEBRATES
YEARS LIVING RADIOISOTOPES