THE USE OF CALCIUM-47 AND STRONTIUM-85 IN DIAGNOSTIC STUDIES

Thesis/Dissertation · Mon Jan 01 04:00:00 EST 1962

OSTI ID:4744828

Corey, K R

Radioisotope techniques were used to study calcium metabolism in healthy and diseased bones. It was decided to use gamm emitting tracers for calcium which would allow in vivo measurements on patients. The best possible r isotope appeared to be Ca/sup 47/ although some studies wer carried out with Sr/sup 85/. Since Ca/sup 47/ was a new radioisoto and was to be used in the human, the technical aspects preparation, and assay had to be developed. The dosimetry was considered and a guide was established for tracer doses of Ca/sup 47/ and Sr/sup 85/. To take full advantage of the isotopes new scanning techniques were developed using a specially constructed scanner. Information about the calcium uptake in normal bones and in various bone lesions were obtained in 48 studies on 33 patients. Many of the studies were complete metabolic studies, including calcium balance and accretion rate determinations. For practical purposes the most important finding was that elevated calcium uptakes occurred in the sites of osseous metastases, whether these were lytic or blastic. With the new scanning technique it was also demonstrated that elevated uptakes could be detected over lesions that were not yet visible on roentgenograms. The applications of the results to the early detection of bone metastases and to other clinical problems are discussed. (Dissertation Abstr., 23: No. 5, Nov. 1982.)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-007708
• OSTI ID: 4744828
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONES
CALCIUM 47
DIAGNOSIS
DISEASES
GAMMA RADIATION
MAN
MEASURED VALUES
MEDICINE
METABOLISM
METASTASES
RADIATION DETECTORS
RADIATION DOSES
STRONTIUM 85
TRACER TECHNIQUES