DETECTION OF BONE METASTASES IN SCANNING STUDIES WITH CALCIUM-47 AND STRONTIUM-85
The HEG scanning system, designed specifically for external counting of high energy gamma rays, was applied towards the diagnosis of bone metastases from breast carcinoma. Studies on six patients are described who had been given intravenous injections of either calcium-47 or strontium-85. In four of these cases there was no evidence of bone metastases and the radioisotope uptakes in a variety of bones were normal. Of particular interest in this work was the distribution of activity along the thoracic spine. With a straight hole collimator in the scanning head, the uptake was found to be iairly constant throughout, although, between the fifth and the nlnth vertebrae, uptakes 10 to 30% larger than above or below were sometimes seen. Two patients had complaints oi pain in the thoracic spine. Elevated uptakes were detected over the painful areas while radiographs were not reported to show bone lesions. The presence of metastases were confirmed in one case by surgery and in the other case after five morths by radiographic examination. The scans of these and other lesions demonstrate that the HEG scanning system with its quantitative read-out has advanced the possibility of detecting and outlining bone lesions and also has made it possible to obtain more precise data on the calcium turnover in the lesions. The scanning technique and the clinical implications of the findings are discussed. (auth)
- Research Organization:
- Sloan-Kettering Inst. for Cancer Research, New York; and Memorial Hospital for Cancer and Allied Diseases, New York
- NSA Number:
- NSA-17-010344
- OSTI ID:
- 4713665
- Journal Information:
- Journal of Nuclear Medicine (U.S.), Journal Name: Journal of Nuclear Medicine (U.S.) Vol. Vol: 3; ISSN JNMEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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