Radiation Studies: Studies of the Kinetic State of Calcium in Bone Lesions, Using Calcium-47 and Strontium-85: Progress Report, June 1, 1963-May 30, 1964

Technical Report · Wed Jul 01 00:00:00 EDT 1964

DOI:https://doi.org/10.2172/4059415· OSTI ID:4059415

Myers, W. P. Laird ^[1]; Greenberg, Ernest ^[1]

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1. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Sloan Kettering Institute

During the period of this report - June 1, 1963 to May 30, 1964 - 34 studies of the distribution and kinetics of Calcium-47 and Strontium-85 were conducted in 33 patients who had cancer metastatic to bone or who were suspected of having such metastases. The results of this work are presently being analyzed and prepared for publication. The studies were carried on with the following objectives: 1. to detect very early metastases which were not apparent by x-ray techniques; 2. to improve and simplify kinetic studies by (a) sampling the saliva instead of the blood, and (b) using the High Energy Gamma (HEG) scanner to measure the total body retention of the isotopes used; 3. to study the effect of radiation treatment on the retention of Ca-47 and Sr-85 by bone lesions; 4. to determine by weekly, then monthly follow-up, the retention in bone of tracer doses of Ca-47 and Sr-85 under various conditions; 5. to study the disappearance rate from blood of a single intravenous dose of tetracycline -- as a pilot study in 7 patients with various bone diseases, in order to develop a non-isotopic technique of following the course of metastatic or metabolic bone disorders by means of a "tetracycline tolerance test".

• Research Organization: Memorial Sloan Kettering Cancer Center, New York, NY (United States). Sloan Kettering Institute
• Sponsoring Organization: US Atomic Energy Commission (AEC)
• DOE Contract Number: AT(30-1)-910
• OSTI ID: 4059415
• Report Number(s): NYO--910-9
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBIOTICS
BIOLOGY AND MEDICINE
BLOOD
BODY
BONES
CALCIUM
CALCIUM 47
CANCER
DIAGNOSIS
DISEASES
DISTRIBUTION
GAMMA DETECTION
MAN
METABOLISM
METASTASES
RADIATION DETECTORS
RADIOTHERAPY
REACTION KINETICS
STRONTIUM 85
TETRACYCLINES
TRACER TECHNIQUES
URINE
WHOLE-BODY COUNTING