THE EFFECT OF X-IRRADIATION ON EXPERIMENTAL PNEUMOCOCCAL INFECTION IN MICE, WITH SPECIAL REFERENCE TO THE INFLUENCE OF THE RADIATION TIME FACTORS
Following whole-body x irradiation, mice were injected intraperitoneally with Diplococcus penumoniae type I after injecting a certain amount of antipneumococcal serum which was expected to protect against the injection. With administration of 500-r dose, the leukocyte count fell immediately, then gradually returned to the normal level. With a dose increased to 1000 r, the mice died due to a dramatic fall in the leukocyte count. A 50-r dose resulted in a transitory rise in the leukocyte count shortly after x irradiation, after which no significant changes were seen. With dose rates of 3.2 and 32 r/min., the injurious effect was less with the low intensity than with the high intensity irradiation. Thus it was concluded that the resistance of mice to pneumococcal infection was lowered inversely proportional to both the dose and the dose rate of x radiation. (Abstr. Japan Med., 2: No. 10, Oct. 1962)
- Research Organization:
- Nihon Univ., Tokyo
- NSA Number:
- NSA-17-004413
- OSTI ID:
- 4742351
- Journal Information:
- Nichidai Igaku Zasshi (Japan), Vol. Vol: 19: Suppl.; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
EFFECT OF THE INTERNAL IRRADIATION BY RADIOACTIVE PHOSPHORUS ON THE HAEMOPOIETIC SYSTEM. II. COMPARISON OF THE EFFECTS OF INTERNAL IRRADIATION BY RADIOACTIVE PHOSPHORUS AND OF WHOLE-BODY X-IRRADIATION ON THE HAEMOPOIETIC SYSTEM
EFFECT OF X-IRRADIATION ON THE FUNCTION OF THE RES IN MICE. I. INFLUENCE OF WHOLE-BODY SINGLE IRRADIATION ON THE FUNCTION OF THE RES