IRRADIATION AS A CAUSE OF MASCULINIZATION IN SUBMAXILLARY GLANDS

Journal Article · Wed Feb 01 04:00:00 EST 1961 · Brit. J. Exptl. Pathol.

OSTI ID:4739412

Berdjis, C C

Histopathologic changes were investigated in male and female rats approximates 1 yr after 500 r whole-body irradiation. Radiation masculinized the submaxillary glands of female rats, as was previously found in mice. Radiation affected both components of submaxillary glands, acini and tubules; more severe changes occurred in the female. The changes included: atrophy, with occluded acini in both sexes, tubular hypertrophy in females; and masculinization with acidophilic granules in the female. Most of the females developed radiation- induced hormone-secreting tumors such as granulosa-cell and masculinized tumors (arrhenoblastoma), in highly atrophic, nonfunctioning ovaries. The tumors seemed to be the cause of masculinization in submaxillary glands and kidneys of irradiated rats. Most of the changes showed the influence of hormonal imbalance related to ovarian injury. The degree of masculinization, as seen by epithelial cells with acidophilic granules, their height, and diameter, can be used as an index of hormonal imbalance in evaluating the ovarian function in rats and mice. (H.H.D.)

• Research Organization: U.S. Army Medical Unit, Fort Detrick, Md.
• NSA Number: NSA-17-005800
• OSTI ID: 4739412
• Journal Information: Brit. J. Exptl. Pathol., Journal Name: Brit. J. Exptl. Pathol. Vol. Vol: 42
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CIRCUITS
CONTROL
CYTOLOGY
GLANDS
GONADS
HORMONES
KIDNEYS
MICE
MICROSCOPY
RADIATION DOSES
RATS
ROTATION
SALIVARY GLANDS
SEX
SWITCHES
TUMORS
VELOCITY