GENERALIZED HYPEROSTOSIS INTERNA AND OSTEOSARCOMA IN WHOLE-BODY IRRADIATED MICE WITH HORMONALLY ACTIVE OVARIAN TUMORS (in German)
Journal Article
·
· Pathologia et Microbiologia (Switzerland) Changed to Exp. Cell Biol.
OSTI ID:4702737
Inbred mice, a Swiss albino subline, at the age of 3 months were submitted to a single, 600-r, whole-body dose of x radiation. Many of the irradiated females developed, with a peak incidence at 12 months, generalized hyperostosis interna as seen by replacement of the blood-forming bone marrow by newly formed bone of the spongiosa type. This finding was consistentiy accompanied by the development of hormonally active, dyplastic or neoplastic ovarian tumors, consisting of granulosa cells or so-called clear cells. Their estrogenic activity was reflected by changes in uterus and vagina, and their androgen secretion by changes in submaxillary glands and kidney (organs with androgen-dependent sexual dimorphism). All animals with clear-cut generalized hyperostosis interna showed signs of persistent and/or excessive estrogen secretary activity. The animals with most severe replacement of marrow by bone showed signs of increased androgen production along with hyperestrogenism. This was accompanied by hypertrophy of the inner zone of adrenal cortical cells. Thie bone pathology was significantiy more frequent in irradiated than nonirradiated females or irradiated males will osteogenic sarcoma. After decalcification, bone samples from hyperostosis interna showed a higher iron content, on the basis of the Turnbull or Berlin blue reactions, than normal bone. (H.H.D.)
- Research Organization:
- Universitat, Bern
- NSA Number:
- NSA-17-028747
- OSTI ID:
- 4702737
- Journal Information:
- Pathologia et Microbiologia (Switzerland) Changed to Exp. Cell Biol., Journal Name: Pathologia et Microbiologia (Switzerland) Changed to Exp. Cell Biol. Vol. Vol: 24; ISSN PAMIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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