EFFECTS OF X-IRRADIATION ON THYMIDINE INCORPORATION IN MICE TREATED WITH S,/ cap beta/-AMINOETHYLISOTHIURONIUM BROMIDE (AET)
Technical Report
·
OSTI ID:4724581
The effect of the radioprotective agent AET on incorporation of labeled thymidine was studied in small intestine, spleen, and thymus of adult mice exposed to 500 r of whole--body x irradiation. Variations of specific activity of DNA show the protective effect of AET as early as the 8th hour post- irradiation in the intestine and 16th hour post-irradiation in the spleen. There is a significant increase of total labeling in the small intestine and in spleen in the irradiated animals protected by AET, as compared with unprotected mice. The data suggest that the recovery in the small intestine is real both in protected and unprotected arimals. In spleen, increase in the specific activity of DNA early after irradiation is probably due to the progressive loss of metabolically inactive DNA. The differences in the specific activities appear much earlier than the differences in the amount of DNA-P in protected and unprotected mice. The protective effect of AET on the labeling of thymus DNA is both decreased and delayed, as compared to that of the small intestine and spleen. (auth)
- Research Organization:
- George Washington Univ., Washington, D.C. School of Medicine
- NSA Number:
- NSA-17-010486
- OSTI ID:
- 4724581
- Report Number(s):
- TID-15931; NYO-10357
- Country of Publication:
- United States
- Language:
- English
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