URINARY EXCRETION OF $sup 32$P AND DESOXYRIBOSE IN RATS FOLLOWING IRRADIATION OR ADMINISTRATION OF A SINGLE DOSE OF METHIONINE SULPHOXIMINE

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Intern. J. Radiation Biol.

OSTI ID:4717036

Kolousek, J; Dienstbier, Z

The urinary excretion of P/sup 32/ was investigated in rats following the intraperitoneal administration of a single dose of 50 mg and 150 mg L- methionine sulfoximine, and compared with the effect of x radiation, the administration of 2,4-dinitrophenol, and scalding of 50 per cent of the body surface. After the administration of a single dose of methionine sulfoximine, the excretion of P/sup 32/ in the urine rises, depending on the amount administered. The effect of methionine sulfoximine and radiation of the urinary excretion of P/sup 32/ is similar. A similar effect is observed after administration of 2,4-dinitrophenol, but scalding has the reverse effect, i.e., the excretion of P/sup 32/ is reduced as compared with controls. After the administration of methionine sulfoximine, as after irradiation there is an increased excretion of Dische-positive substances, i.e., of urinary desoxyribose in rats. The increased urinary excretion of P/sup 32/ and desoxyribose in rats may be due to a disorder in the mechanism of oxidative phosphorylation. (auth)

• Research Organization: Charles Univ., Prague
• NSA Number: NSA-17-027037
• OSTI ID: 4717036
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 6
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
DEOXYRIBOSE
DNP
METABOLISM
METHIONINE
ORGANIC NITROGEN COMPOUNDS
PHENOLS
PHOSPHORUS 32
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION EFFECTS
RADIATION INJURIES
SCALING
SUGARS
THERMAL RADIATION
URINE
X RADIATION