THE INFLUENCE OF METHIONINE SULFOXIMINE ON THE LIVER AND SPLEEN OF RATS (in Czech)
Journal Article
·
· Acta Univ. Carolinae Med., Suppl.
OSTI ID:4739050
Studies were made of the influence of DL-methionine sulfoximine on the incorporation of S/sup 35/ in the protein, nonprotein, and lipid fractions of liver and on the urinary excretion of S/sup 35/ in rats. Stimulation of methionine-S/sup 35/ uptake by spleen occurred 6 hr after treatment with methionine sulfoximine and persisted after 24 hr, whereas in liver the stimulation was slight. A single intraperitoneal injection of 400 mg/kg methionine sulfoximine produced fatty degeneration of liver. In contrast, in spleen it resulted in a decrease in total lipid, phospholipid, and esterified fatty acid content. The injection also produced changes in blood cell counts, which were simulated by x irradiation of the rats with 50 r. Moreover, both x irradiation and injection of methionine sulfoximine caused an increase in the urinary excretion of Dische-positive substances, presumably catabolites of DNA. In rats irradiated with 600 r and injected 1 hr later with methionine-S/sup 36/, a radioinduced rise in urinary excretion of S/sup 35/, which paralleled the increase in excretion of Dische-positive substances, was noted. A similarity in the mechanism of action of methionine sulfoximine and ionizing radiation is suggested. This compound was also found to decrease the incorporation of P/sup 32/ in cytoplasmic RNA 59%. (P.C.H.)
- Research Organization:
- Charles Univ., Prague
- NSA Number:
- NSA-17-017712
- OSTI ID:
- 4739050
- Journal Information:
- Acta Univ. Carolinae Med., Suppl., Journal Name: Acta Univ. Carolinae Med., Suppl. Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- Czech
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OSTI ID:4325096