THE INFLUENCE OF METHIONINE SULFOXIMINE ON METABOLISM OF RATS IN COMPARISON WITH RADIATION DISEASE
The effect of a single intraperitoneal dose of methionine sulfoximine (MSI) on the incorporation of DL-methionine-S/sup 35/ in rat tissues was studied. MSI stimulated incorporation of S/sup 35/ into proteins in spleen, but in liver S/ sup 35/ uptake by protein was diminished and activity in nonprotein fractions was lower than in controls. Excretion of S/sup 35/ in urine was doubled 6 hr after injection of MSI. A single injection of MSI reduced the spleen content of esterified fatty acids, free, and total lipids but no change in cholesterol and phospholipids. Blood showed a rise in neutrophils and a fall in lymphocytes and reticulocytes. In urine a marked rise occurred in the intensity of the Dische reaction for deoxyribose, a change previously noted in radiation disease. X irradiation of rats with 600 r also elevated the urinary excretion of S/sup 35/ after administration of methionine-S/sup 35/. MSI diminished the incorporation of P/sup 32/ in cytoplasmic ribonucleic acid st run. Concent 59%. It is suggested that MSI and radiation have analogous modes of actions. (H.H.D.)
- Research Organization:
- Charles Univ., Prague
- NSA Number:
- NSA-17-021437
- OSTI ID:
- 4694286
- Journal Information:
- Klin. Wochschr., Journal Name: Klin. Wochschr. Journal Issue: 7 Vol. Vol: 39; ISSN 0023-2173
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
THE INFLUENCE OF METHIONINE SULFOXIMINE ON THE LIVER AND SPLEEN OF RATS
URINARY EXCRETION OF $sup 32$P AND DESOXYRIBOSE IN RATS FOLLOWING IRRADIATION OR ADMINISTRATION OF A SINGLE DOSE OF METHIONINE SULPHOXIMINE
OBSERVATIONS ON THE OXIDATION OF METHIONINE-S$sup 35$ TO S$sup 35$O$sub 4$ AND TAURINE-S$sup 35$ IN THE X-IRRADIATED RAT
Journal Article
·
Sat Dec 31 23:00:00 EST 1960
· Acta Univ. Carolinae Med., Suppl.
·
OSTI ID:4739050
URINARY EXCRETION OF $sup 32$P AND DESOXYRIBOSE IN RATS FOLLOWING IRRADIATION OR ADMINISTRATION OF A SINGLE DOSE OF METHIONINE SULPHOXIMINE
Journal Article
·
Thu Feb 28 23:00:00 EST 1963
· Intern. J. Radiation Biol.
·
OSTI ID:4717036
OBSERVATIONS ON THE OXIDATION OF METHIONINE-S$sup 35$ TO S$sup 35$O$sub 4$ AND TAURINE-S$sup 35$ IN THE X-IRRADIATED RAT
Technical Report
·
Tue Oct 21 00:00:00 EDT 1958
·
OSTI ID:4325096