LIPOXIDASE AND IONIZING RADIATIONS
Since ionizing radiation and lipoxidase, a soybean enzyme which oxidizes unsaturated fatty acids, both act on biological systems by the formation of peroxides, it was of interest to determine whether their effects are synergistic. In mice given a lethal (800-r) dose of whole-body x irradiation 1 hr after injection of 250 mg/kg lipoxidase, the mortality curve was similar to that of animals receiving radiation alone, except on the 3rd day when the rate was slightly higher in animals treated with both enzyme and x rays. In another group of mice injected with 62 to 250 mg/kg lipoxidase before sublethal (450-r) irradiation, the enzyme only slightly increased the death rate after the 15th day. Thus, no consistent potentiating action of lipoxidase on radiation injury could be demonstrated. (H.H.D.)
- Research Organization:
- Institut de Pharmacologie de la Faculte de Medecine, Paris
- NSA Number:
- NSA-17-017921
- OSTI ID:
- 4715237
- Journal Information:
- Bull Acad. Natl. Med. (Paris), Journal Name: Bull Acad. Natl. Med. (Paris) Vol. Vol: 145
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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