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U.S. Department of Energy
Office of Scientific and Technical Information

PREVENTION OF LATE DEATHS IN X-IRRADIATED MICE BY INJECTED HEMATOPOIETIC CELLS OF NEWBORN DONORS

Technical Report ·
OSTI ID:4325213
When mice are exposed to a single sublethal dose of x radiation (500 r) and injected with normal spleen cells obtained from adult parental strain mice, delayed deaths during the 2nd, 3rd, and 4th weeks with symptoms of general debilitation, body weight loss, and lymphoid atrophy occur in 100% of the animals. Lethal effect is dependent in part on the size of the spleen cell inoculum. The lethal effect is not duplicated by the injection of lysed spleen cells, by liver cells, or by spleen cells derived from newborn parental strain mice. The injection of cells from liver, spleen, or marrow of newborn A-strain mice into lethally x-irradiated LAF/sub 1/ mice provides up to 100% protection at 30 days, and elicits no late homologous deaths. (auth)
Research Organization:
Naval Radiological Defense Lab., San Francisco
NSA Number:
NSA-12-013687
OSTI ID:
4325213
Report Number(s):
USNRDL-TR-245
Country of Publication:
Country unknown/Code not available
Language:
English