LETHAL GRAFT VERSUS HOST REACTION INDUCED IN X-IRRADIATED F$sub 1$ HYBRIDS BY PARENTAL STRAIN LEUKOCYTES

Technical Report · Tue Feb 10 04:00:00 EST 1959

OSTI ID:4269442

Cole, L J; Garver, R M; OKunewick, J P

The experimental findings show that the injection of parental strain (A or L strain) whole blood, containing 15 x 10/sup 6/ nucleated cells, into sublethally x-irradiated (500 r) LAf/sub 1/ mice, results in delayed deaths, i.e., from 8 to 39 days post irradiation. The reneral appearance of these injected mice, thcir body weight loss, and the histological evidence as specific lymphoid tissue atrophy indicate that thc syndrome produced is entirely analogous to that observed previously following spleen cell injection. The effect is referable to the leukocytes and not to the erythrocytes or scrum. Since lymph node cells, as well as spleen cells elicit these delayed deaths, it is reasonable to postulate that the responsible cells are those of the lymphoid series. These results imply that peripheral blood contains immunologically competent cells. On this basis, it is suggested that the administration of whole blood or agranulocytic leukocytes from non-isologous donors to heavily irradiated recipients constitutes a potentially hazardous procedure. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-13-010781
• OSTI ID: 4269442
• Report Number(s): USNRDL-TR-296
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD CELLS
BODY
CYTOLOGY
ERYTHROCYTES
HYBRIDS
IMMUNITY
LETHAL DOSE
LEUCOCYTES
LYMPH SYSTEM
LYMPHOCYTES
MICE
QUANTITY RATIO
SENSITIVITY
SPLEEN
SURVIVAL TIME
TISSUES
TRANSPLANTS
VARIATIONS
WEIGHT
X RADIATION