EFFECTS OF X IRRADIATION ON THE MUCOPOLYSACCHARIDES IN THE AORTIC WALL
Journal Article
·
· Acta Physiologica et Pharmacologica Neerlandica (Netherlands) Discontinued with Vol. 15, no. 4, 1970
OSTI ID:4715016
>The effects of irradiation on aortic mucopolysaccharides were investigated in vitro and in vivo. Injection pressure in media and intima drops instantaneously during in vitro irradiation of aorta with 1000 r, indicating an increased water permeability. Diffusion of dyes into the intimal layer occurred at an increased rate in x irradiated segments of excised aorta (human, cow, pig, dog). Injection of dye solutions in rats after whole-body irradiation (3000 r), followed by spectrophotometric estimation of dye content in the intimal membrane, demonstrated an increased accumulation of dye (trypan blue, Evans blue, hematoporphyrin) in comparison with measurements on aortas of nonirradiated control animals. In experiments with rabbits fed on a high cholesterol diet, irradiation with 100 r weekly for 10 weeks resulted in a higher incidence of atheromatous lesions, compared with nonirradiated animals fed the same diet. The presence of Na/sub 2/S/sub 2/O/sub 3/ provided an effective protection against the drop of injection pressure and the increased diffusion rate of dyes after irradiation. It is suggested that the described vascular radiation efiects may contribute to the shortening of lifespan after subletual and chronic irradiation and that Na/sub 2/S/sub 2/O/sub 3/ may have protective value against these effects. The results suggest that mucopolysaccharide depolymerization is caused by x irradiation, which is reflected by increased permeability of the aorta. (TCO)
- Research Organization:
- Universiteit, Groningen, Netherlands
- NSA Number:
- NSA-17-024904
- OSTI ID:
- 4715016
- Journal Information:
- Acta Physiologica et Pharmacologica Neerlandica (Netherlands) Discontinued with Vol. 15, no. 4, 1970, Journal Name: Acta Physiologica et Pharmacologica Neerlandica (Netherlands) Discontinued with Vol. 15, no. 4, 1970 Vol. Vol: 11; ISSN APPNA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
EARLY EFFECTS OF X IRRADIATION ON THE PERMEABILITY OF EXCISED AND LIVING AORTA WALL
INFLUENCE OF ARTIFICIAL HIBERNATION ON THE PHENOMENON OF DIFFUSION IN THE SKIN EXPOSED TO IONIZING RADIATION
Modification in the transmural concentration of cholesterol and the transmural distribution of /sup 131/I-albumin in the aortas of pigs fed cholesterol: a preliminary report
Journal Article
·
Thu Dec 31 23:00:00 EST 1959
· Koninkl. Ned. Akad. Wetenschap., Proc., Ser. C
·
OSTI ID:4679842
INFLUENCE OF ARTIFICIAL HIBERNATION ON THE PHENOMENON OF DIFFUSION IN THE SKIN EXPOSED TO IONIZING RADIATION
Journal Article
·
Mon Oct 31 23:00:00 EST 1960
· Arch. Ital. Dermatol. Venereol. Sessuol.
·
OSTI ID:4680137
Modification in the transmural concentration of cholesterol and the transmural distribution of /sup 131/I-albumin in the aortas of pigs fed cholesterol: a preliminary report
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· Artery (Fulton, Mich.); (United States)
·
OSTI ID:6441262