EARLY EFFECTS OF X IRRADIATION ON THE PERMEABILITY OF EXCISED AND LIVING AORTA WALL

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Koninkl. Ned. Akad. Wetenschap., Proc., Ser. C

OSTI ID:4679842

Brinkman, R; Lamberts, H B; Bottema, J K

Experiments are reported that demonstrate an increase of permeability of aortic tissue after irradiation, presumably as a result of the depolymerization of mucopolysaccharides (MPS). A drop in injection pressure of the aorta followed irradiation with 500 r. The increased permeability of irradiated aorta could also be demonstrated by a dye technique in which infiltration of trypan blue into the intima was demonstrated. Penetration of dye following irradiation was diminished if physiologic pressure in the lumen was maintained. In rats the increased aortic infiltration could be demonstrated readily. If the rat received 1000 to 3000 r whole-body x irradiation, was injected 10 min later intravenously with 0.4 ml/100 g of a 1% solution of Congo red in 5% glucose, and was killed after 30 min, the aorta of the irradiated rat was distinctly more stained than that of nonirradiated animals, indicating increased macromolecular infiltration through the mucopolysaccharide barrier. If 1 mg/g sodium thiosulfate was given subcutaneously just before irradiation, the aorta was completely protected. No consistent protective effect was demonstrated with aminoethylisothiuronium, cysteamine, cystamine, or serotonin. (TCO)

• Research Organization: Univ. of Groningen, Netherlands
• NSA Number: NSA-17-024947
• OSTI ID: 4679842
• Journal Information: Koninkl. Ned. Akad. Wetenschap., Proc., Ser. C, Journal Name: Koninkl. Ned. Akad. Wetenschap., Proc., Ser. C Vol. Vol: 64
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD VESSELS
BODY
CHEMICALS
CONGO RED
DIFFUSION
DYES
ITALY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RATS
SODIUM SULFATES
SULFATES
THIOSULFATES
X RADIATION