ACTION OF ANTIRADIATION DRUGS AND THE "OXYGEN EFFECT"
The dependence of antiradiation protection on density of ionization was checked experimentally by exposing white mice to whole-body irradiation by 660- Mev protons. The average density of the pulsed proton beam was 10/sup 8/ to 10/ sup 9/ proton/cm/sup 2//sec. Pulse duration varied from 200 to 400 sec. The rate of pulsation was 100 pulses/min, so that the actual density and corresponding absorption dose were 10 to 50 times as high. The minimum absolute lethal dose for mice was 1200 to 1300 rad. Antiradiation drugs administered were: cysteamine ( BETA -mercaptoethylamine), serotonin (5-oxytriptaminecreatinin sulfate), S'' ( BETA -aminoethylisothiuronium bromide), cystamine (disulfide- cystamine dichlorhydrate), and hydroxylamine (hydroxylamine chlorhydrate). All drugs were administered intraventrally in physiological saline 10 to 15 min before irradiation, except cystamine, which was administered 30 min before irradiation. Dosage was 150 mg/kg, except for serotonin (50 mg/ kg) and hydroxylamine (60 mg/kg). All the drugs improved resistance to radiation, drug S'' being the most effective. The experiments demonstrated the effectiveness of drugs against radiation by high-energy protons. The results are regarded as an indirect confirmation of the oxygen effect and of the dependence of effectiveness of chemical protection on the relative density of ionization. (TCO)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-021590
- OSTI ID:
- 4694126
- Journal Information:
- Probl. Kismich. Biol., Vol. Vol: 2; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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