THE MECHANISM OF ACTION OF ANTIRADIATION AGENTS

Journal Article · Sat Jun 01 04:00:00 EDT 1963 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4666946

Kuznetsov, V I; Kushakovskii, M S

Investigations were made on the influence of cystamine hydrochloride and S, beta-aminoethylisothiuronium hydrobromide on the oxygen balance in the human organism. Cystamine in peroral doses of 200-600 mg causes a rise of the basal metabolism, increased oxygen consumption in the lungs, intensified respiration of erythrocytes (in the presence of glucose), and reduction of methemoglobin. S, beta-aminoethylisothiuronium in similar doses causes a drop of the basal metabolism and a diminution of the coefficient of oxygen consumption in the lungs. S,-beta-aminoethylisothiuronium, in contrast to cystamine, penetrates the erythrocyte membrane but weakly. A supposition is made on the diverse mechanisms of antiradiation effect of the preparations. (auth)

• Research Organization: Kirov Military-Medical Academy of Order of Lenin, USSR
• NSA Number: NSA-17-031833
• OSTI ID: 4666946
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 8: No. 6; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AET
AMINES
BIOLOGY AND MEDICINE
CYSTAMINE
CYSTEINE
DIFFUSION
ERYTHROCYTES
HEMOGLOBIN
LUNGS
MAN
MEMBRANES
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
QUANTITY RATIO
RADIATION PROTECTION
REDUCTION
SUGARS
VARIATIONS