THE OXYGEN EFFECT IN THE CASE OF WHOLE-BODY EXPOSURE TO HIGH-ENERGY PROTONS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4770488

Yaromonenko, S P; Avrunina, G A; Shashkov, V S; Govorun, R D

Most studies on radiation protection were carried out with gamma rays which possess high penetrating power and low ionization density; therefore the protection of mice against the effects of whole-body irradiation with 660-Mev protons was investigated. The beam from the synchrocyclotron of the Joint Institute of Nuclear Investigation had an average flux density of 10/suo 8/ to 10/ sup 9/ protons/cm/sup 2/ sec and a dose rate of 3 to 400 rad/min; the pulses lasted 2 to 400 microseconds at a frequency of about 100/sec. Radioprotective materials, such as BETA -mercaptoethylamine hydrochloride, cysteine dihydrochloride, S, BETA -aminoethylisothiuronium bromide hydrobromide, 5- oxytryptamine, creatinine sulfate (serotinine), and 5-methoxytryptamine hydrochloride were introduced into the white mice l0 to 15 minutes prior to the irradiation in doses of 1 to 3 mg. Results indicated that all the preparations tried exerted a protective action, as evidenced by the increase of the survival rate and the increase of the average life span of the animals. This action was due to the reduction of the ionization density of the beam and provided an indirect proof concerning the validity of the oxygen effect in biological protection. This effect, described by P. Bonet-Maury (Disc. Faraday Soc., 12: 72(1952)), involves the increase of the H/sub 2/O/sub 2/ yield as a function of particle yield in the irradiation of water. (TTT)

• Research Organization: Inst. of Industrial Hygiene and Occupational Diseases, Moscow
• NSA Number: NSA-16-030305
• OSTI ID: 4770488
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AET
AMINES
BIOLOGY AND MEDICINE
BODY
CHEMICALS
CYCLOTRONS
CYSTEINE
ENERGY LEVELS
ETHYL RADICALS
FREQUENCY
GAMMA RADIATION
HETEROCYCLICS
HYDROGEN PEROXIDES
INDOLES
LIFETIME
MEA
METHOXY RADICALS
MICE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
PARTICLES
PROTON BEAMS
PULSES
RADIATION DOSES
RADIATION PROTECTION
SEROTONIN
TRYPTAMINES
WATER