Modification in the transmural concentration of cholesterol and the transmural distribution of /sup 131/I-albumin in the aortas of pigs fed cholesterol: a preliminary report

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Artery (Fulton, Mich.); (United States)

OSTI ID:6441262

Bell, F P

Transmural cholesterol concentrations and transmural distribution of intravenously injected /sup 131/I-albumin were measured simultaneously in the aorta of both normal and cholesterol-fed pigs. The characteristic profile of /sup 131/I-distribution across the normal pig aorta in areas of high and low permeability (as identified by Evans Blue dye) is modified by cholesterol feeding. Additionally, the transmural concentration of cholesterol, which is similar in areas of high and low permeability of the normal pig aorta, is remarkably higher in the intima of high permeability areas of aortas of cholesterol-fed pigs and suggests that differential permeability in focal areas of the aorta is important only under conditions of hyperlipemia.

• Research Organization: Diabetes and Atherosclerosis Research, Upjohn Company, Kalamazoo, Michigan
• OSTI ID: 6441262
• Journal Information: Artery (Fulton, Mich.); (United States), Vol. 12:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHOLESTEROL
BLOOD CHEMISTRY
ALBUMINS
AORTA
CAPILLARIES
DIET
IODINE 131
PERMEABILITY
SWINE
TRACER TECHNIQUES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
STEROIDS
STEROLS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques