INFLUENCE OF ARTIFICIAL HIBERNATION ON THE PHENOMENON OF DIFFUSION IN THE SKIN EXPOSED TO IONIZING RADIATION

Journal Article · Tue Nov 01 04:00:00 EST 1960 · Arch. Ital. Dermatol. Venereol. Sessuol.

OSTI ID:4680137

Moroni, P

Attempts were made to alter the reaction of depolymerization of mucopolysaccharides in the skin following irradiation by submitting guinea pigs to hypothermia. The animals were injected with 5 mg trifluoropromazine intraperitoneally, which resulted in a 2.5 deg drop in body temperature 1 hr later. Skin was locally irradiated with 1000-r doses of 50-kv x rays 1 hr after intracutaneous injection of a 0.1% solution of trypan blue. Irradiation of the skin of untreated arimals (nonhypothermic) resulted in increased diffusion of the dye in both control and irradiated areas of skin, but the effect was more pronounced in irradiated regions. One hr after irradiation the diffusion area was double that found in unirradiated animals and 24 hr later it was 10 and 30 times greater, respectively, in control and irradiated regions of skin. Hypothermia markedly diminished the diffusion area in irradiated but not in unirradiated skin; the area was only 4 times greater than normal in contrast to the 30-fold increase in nonhypothermic animals. Also, diffusion reached a maximum at about 6 hr postirradiation in hypothermic animals in contrast to the area controls, which continued to expand for 24 to 36 hr. The results indicate that in the hibernating state the ground substance mucopolysaccharides are less vulnerable to the depolymerizing action of ionizing radiation. (TCO)

• Research Organization: Universita, Bologna
• NSA Number: NSA-17-024908
• OSTI ID: 4680137
• Journal Information: Arch. Ital. Dermatol. Venereol. Sessuol., Journal Name: Arch. Ital. Dermatol. Venereol. Sessuol. Vol. Vol: 30
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
DIFFUSION
DYES
GUINEA PIGS
LOW TEMPERATURE
RADIATION DOSES
RADIATION EFFECTS
SKIN
X RADIATION