Acute and Chronic Toxicity of Inhaled Plutonium in Dogs

Journal Article · Mon Jan 01 00:00:00 EST 1962 · Health Physics

DOI:https://doi.org/10.1097/00004032-196212000-00013· OSTI ID:4713987

Park, J. F.; Willard, D. H.; Marks, S.; West, J. E.; Vogt, G. S.; Bair, W. J.

Beagle dogs were given single exposures to Pu²³⁹O₂ aerosols. Deposition of 0.9 to 0.1 mu c/g of lung caused death in 31 dogs in 55 to 412 days after exposure. Average radiation dose to lungs was 4000-14,000 rads. Lymphopenia, polypnea, weight loss and bradycardia developed prior to death. Gross and histopathlogic tissue changes were limited to the lungs and associated lymph nodes, which contained 99 per cent of the plutonium content of the dog. One dog died 862 days following deposition of approximately 0.05 mu c/g of lung. Dogs exposed to lesser quantities of plutonium appear normal 2 to 21/2 years after exposure except for lymphopenia.

• Research Organization: General Electric Co., Richland, Wash.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-010322
• OSTI ID: 4713987
• Journal Information: Health Physics, Vol. 8, Issue 6; Other Information: Orig. Receipt Date: 31-DEC-63; ISSN 0017-9078
• Publisher: Health Physics Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
AEROSOLS
BODY
DOGS
HEART
LUNGS
LYMPHOCYTES
PHYSIOLOGY
PLUTONIUM 239
PLUTONIUM OXIDES
QUANTITY RATIO
RADIATION DOSES
TOXICITY
WEIGHT