Hematological effects of inhaled plutonium dioxide in beagles
- Pacific Northwest Lab., Richland, WA (United States); and others
A life-span study indicated that plutonium activity in the thoracic lymph nodes is a contributor to development of lymphopenia in beagles exposed to {sup 239}PuO{sub 2}. Significant lymphopenia was found in 67 (58%) beagles given a single nose-only exposure to {sup 239}PuO{sub 2} to result in mean initial lung depositions ranging from 0.69 to 213.3 kBq. Lymphoid atrophy and sclerosis of the thoracic lymph nodes and lymphopenia were observed in exposure-level groups with initial lung depositions {ge}2.5 kBq. Those dogs with final plutonium concentrations in the thoracic lymph nodes {ge}0.4 kBq/g and dose rates {ge}0.01 Gy/day developed lymphopenia. Marked differences existed between chronically lymphopenic dogs and intermittently lymphopenic dogs with regard to initial lung deposition, time to lymphopenic events and absolute lymphocyte concentrations. Linear regression analysis revealed moderate correlation between reduction in lymphocyte values and initial lung deposition, in both magnitude and time of appearance after exposure. Cumulative dose and dose rate appeared to act together to produce initial effects on lymphocyte populations, while dose rate alone appeared to be responsible for the maintenance and subsequent cycles of lymphopenia seen over the life span. No primary tumors were associated with the thoracic lymph nodes in this study, although 70% of the lymphopenic dogs developed lung tumors. 28 refs., 2 figs., 7 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 121708
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 143; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
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