Acute and Chronic Toxicity of Inhaled Plutonium in Dogs
Journal Article
·
· Health Physics
Beagle dogs were given single exposures to Pu239O2 aerosols. Deposition of 0.9 to 0.1 mu c/g of lung caused death in 31 dogs in 55 to 412 days after exposure. Average radiation dose to lungs was 4000-14,000 rads. Lymphopenia, polypnea, weight loss and bradycardia developed prior to death. Gross and histopathlogic tissue changes were limited to the lungs and associated lymph nodes, which contained 99 per cent of the plutonium content of the dog. One dog died 862 days following deposition of approximately 0.05 mu c/g of lung. Dogs exposed to lesser quantities of plutonium appear normal 2 to 21/2 years after exposure except for lymphopenia.
- Research Organization:
- General Electric Co., Richland, Wash.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-010322
- OSTI ID:
- 4713987
- Journal Information:
- Health Physics, Journal Name: Health Physics Journal Issue: 6 Vol. 8; ISSN 0017-9078
- Publisher:
- Health Physics Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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