HEMATOPOIETIC STUDIES IN X-IRRADIATED NEWBORN RATS
Journal Article
·
· Acta Haematologica (Switzerland)
In rats given 200 r on the 1st day of life, red cell counts, hemoglobin concentrations, and hematocrit vaiues fell sharply to half the initial values by the 10th day, but recovered rapidly. On the other hand, similarly irradiated adult rats showed only small depression in these values. The linear fall observed in the mean volume of the large fetal red cells of normal newborn rats was retarded by x radiation, and may represent an inhibition of x rays on the formation of additional smaller red cells of the adult variety. A very rapid and severe decrease occurred in the white cell counts of the irradiated adult and baby rats. Recovery was rapid in the adults, with essentially normal values attained by the 15th day. However, in the newborn animals, the return to control levels was deiayed until the 40th day. The reduction observed in the numbers of circulating erythrocytes and leukocytes of the irradiated newborn rats paralleled the depletion noted in the cellular elements of the bone marrow. It was concluded that the greater sensitivity to x radiation of the hematopoietic processes of newborn animals is a reflection of their rapid growth rate, which imposes a greater burden on these processes than in the adult. The decrease observed in mean red cell volume with maturation in both normal and irradiated newborn animals supports the hypothesis of an abrupt transition from the production of the larger, fetal red cells to the smaller, adult type at about the time of birth. It was also concluded that the life span of the fetal red cell is relativeiy long, in comparison to the 65-day longevity of the adult red cell. (H.H.D.)
- Research Organization:
- New York Univ., New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-010368
- OSTI ID:
- 4713389
- Journal Information:
- Acta Haematologica (Switzerland), Journal Name: Acta Haematologica (Switzerland) Vol. Vol: 25; ISSN ACHAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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