ENDOTOXIN-INDUCED TOLERANCE TO TOXIC MANIFESTATIONS OF CANDIDA ALBICANS

Journal Article · Wed May 01 04:00:00 EDT 1963 · Journal of Bacteriology (U.S.)

OSTI ID:4712665

Hasenclever, H F; Mitchell, W O

Mice exposed to 425 r total-body irradiation failed to become tolerant to Candida albicans toxicity after injection with lipopolysaccharide. Mice injected with lipopolysaccharide and then x rayed did not demonstrate the tolerant state. An injection of thorium dioxide in mice that had previously received tolerance-inducing amounts of lipopolysaccharide rendered them as susceptible to acute C. albicans toxicity as control mice. A bimodal manifestation of tolerance was noted. Groups of mice given single injections of lipopolysaccharide at 6 or 1 days before challenge demonstrated high levels of tolerance, whereas the tolerance in mice given a single dose at 3 days was negligible. The bimodal effect was not observed in tolerant mice challenged with lipopolysaccharide. Injections of viable or nonviable pathogenic fungi known to produce tolerance to the toxicity of C. albicans in recipient mice did not produce tolerance to lipppplysaccharide. Serum from mice injected with lipopolysaccharide showed in vitro inhibitory activity for C. albicans. (auth)

• Research Organization: National Inst. of Allergy and Infectious Diseases, Bethesda, Md.
• NSA Number: NSA-17-023116
• OSTI ID: 4712665
• Journal Information: Journal of Bacteriology (U.S.), Journal Name: Journal of Bacteriology (U.S.) Vol. Vol: 85; ISSN JOBAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD SERUM
BODY
CANDIDA
CONTROL
FUNGI
IMMUNITY
LIPIDS
LIPOPOLYSACCHARIDES
MICE
POLYSACCHARIDES
QUANTITY RATIO
RADIATION DOSES
THORIUM OXIDES
TOXICITY
VARIATIONS
X RADIATION